Erbium:Yag Laser vs Hyaluronic Acid Suppository for GSM in Breast Cancer (BC)
All women from the outpatient department with a history of BC and GSM (genitourinary symptoms of menopause) symptoms will be invited to participate. After informed consent patients are either randomized to intravaginal laser or hyaluronic acid suppository treatment intravaginally, respectively. Laser treatment will be performed twice, at baseline and after 1 month. The intravaginal hyaluronic acid suppository therapy will be applied daily during the first 10 days and then every third day until the three months follow-up. At baseline and three months follow-up the following questionnaires will be filled out (VAS, (PGI-I, PGI-S, Female Sexual health questionnaire (EORTC), Baessler questionnaire, EORTC quality of life questionnaire, ZUF-8).
• genital symptoms of dryness/ burning/ irritation
‣ and/ or lack of lubrication during sexual intercourse/ sexual discomfort or pain
⁃ and/or symptoms of urgency and dysuria or recurrent urinary tract infection
• Age 18-80
• History of BC and/ or DCIS
• Completed locoregional therapy
• Current antihormonal therapy for BC possible
• Intravaginal treatment with creams/ suppositories other than study medicationshould be ceased during the trial